Arbor Research Collaborative for Health -- Publication Details

CITATION:
Tentori F. Mineral and bone disorder and outcomes in hemodialysis patients: Results from the DOPPS. Semin Dial 2010; 23(1): 10-14

ABSTRACT:
In recent years, increasing attention has been paid to the role of nonclassical risk factors in the development and progression of cardiovascular disease among patients with chronic kidney disease (CKD). The metabolic changes that characterize CKD mineral and bone disorder (MBD) have been associated with increased cardiovascular calcification (1–3) and arterial dysfunction (4,5), which in turn appear to contribute to higher morbidity and mortality (6,7). The National Kidney Foundation Kidney Disease Outcomes Quality Initiative guidelines have indicated that therapeutic regimens aimed at normalization of mineral bone disorder markers may improve outcomes of CKD patients (8). A similar approach was also endorsed by the recently published Kidney Disease Improving Global Outcomes guidelines (KDIGO) (9). The detailed data collected in the Dialysis Outcomes and Practice Patterns Study (DOPPS) across 12 countries over a 13-year period have led to a large number of publications in the area of CKD-MBD (10–16). In the current report, we summarize the most recent DOPPS findings on this topic, specifically regarding [1] trends in serum levels of MBD markers, [2] the association of MBD markers with mortality risk, and [3] insights into the relationship of vitaminDtherapy to clinical outcomes.