New Research from A2ALL Shows Benefits of Living Donor Liver Transplant

Living donor liver transplantation has emerged as an important source of organs when there is a critical scarcity of livers from deceased donors. A new study from the Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL) compares the long-term survival of living donor liver transplant (LDLT) at experienced transplant centers to outcomes of deceased donor liver transplant (DDLT).

The A2ALL study group found that LDLT can have equal long-term outcomes to DDLT when risk-adjusted. Given that patients usually have to wait longer and become sicker before organs become available from deceased donors, living donor liver transplants can provide better outcomes for patients who are transplanted at an earlier stage.

Patients undergoing LDLT showed significant long-term transplant benefit resulting in transplantation at a lower MELD score, decreased death on waitlist, and excellent post-transplant outcomes, and the authors suggest that LDLT should be considered as a primary option for many patients at the time of evaluation. Authors of this study also noted factors that should be considered when making decisions about the timing and options for transplant, including: recipient diagnosis, disease severity, renal failure, and ages of recipient and donor.

Research reported in this publication was supported by National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under award number 5U01DK062498. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

CITATION:Olthoff KM, Smith AR, Abecassis M, Baker T, Emond JC, Berg CL, Beil CA, Burton JR Jr, Fisher RA, Freise CE, Gillespie BW, Grant DR, Humar A, Kam I, Merion RM, Pomfret EA, Samstein B, Shaked A. Defining Long-term Outcomes With Living Donor Liver Transplantation in North America. Ann Surg. 2015 Sep;262(3):465-75.
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