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The fibrotic liver disease that is associated with Biliary Atresia (BA) impacts the likelihood of survival with native liver. Our previously research demonstrated the potential for a certain profibrotic signaling pathway to be active in BA. Using a mouse model of BA and human liver gene expression data collected by ChiLDReN, we were able to confirm the likely activation of this pathway known as TWEAK/FN14 in association with liver fibrosis. We further showed that inhibition of this pathway pharmacologically was associated with near complete elimination of fibrosis in the mouse model of BA. These observations suggest that focus on this signaling pathway warrants further study as we seek novel ways to care for infants with BA.
Arbor Research Collaborative for Health (Arbor Research), a leading provider of innovative solutions in healthcare research, is pleased to announce its participation in the upcoming World Congress of Nephrology (WCN) 2024, scheduled to take place from April 13th to 16th, 2024. The WCN 2024 conference, organized by the International Society of Nephrology (ISN), is a […]
Arbor Research is pleased to announce the appointment of Dr. Steve Hines, PhD as a Senior Research Scientist focusing on health services research and strategic partnerships. Dr. Hines brings a wealth of experience and expertise, having most recently led learning community activities for the AHRQ-funded TAKEheart project while his work updating AHRQ’s TeamSTEPPS training curriculum […]
Advancing the scientific understanding of kidney disease to inform healthcare practice and policy is at the core of Arbor Research’s history. Founded in 1996 in Ann Arbor, Michigan by three leaders in chronic kidney disease care and research, we were originally named the University Renal Research and Education Association (URREA). Arbor Research’s first project was […]
The Dialysis Outcomes and Practice Patterns Study (DOPPS) Program at Arbor Research Collaborative for Health is pleased to share their recent publication recognized as one of the most- downloaded articles at Kidney International Reports in the past few weeks titled “Alkaline Phosphatase and Parathyroid Hormone Levels: International Variation and Associations With Clinical Outcomes in the […]