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Portal hypertension is a complication of children with biliary atresia. It results from progression of liver scarring (fibrosis) and can lead to gastrointestinal bleeding and accumulation of fluid in the abdomen (also known as ascites). In this study, investigations from the Childhood Liver Disease Research Network analyzed the blood of patients to identify protein that increase in children with portal hypertension. Investigators analyzed over 1,000 proteins using an assay known as proteomics. Among the proteins that increased in babies with portal hypertension they found that semaphorin 6B (SEMA6B) alone and three other protein combinations (SEMA6B+SFRP3, SEMA6B+COMMD7, and VCAM1+BMX) had high accuracy to identify portal hypertension. Analyzing liver biopsies, the new protein biomarkers showed increased expression in liver vascular cells (endothelial cells), bile duct epithelium (cholangiocytes), and immune cells within portal triads.
Conclusion
Large-scale proteomics identified SEMA6B, SFRP3, COMMD7, BMX, and VCAM1 as biomarkers highly associated with clinical portal hypertension in children with biliary atresia. The expression of the biomarkers in liver epithelial, endothelial, and immune cells support their potential role in the mechanisms that cause portal hypertension.
Arbor Research Collaborative for Health is proud of its role as the Data Coordinating Center for the Worldwide Integration of Natural History Databases for Primary Sclerosing Cholangitis (WIND-PSC) study, a groundbreaking research initiative led by PSC Partners and PSC Partners Canada. These patient-led non-profit organizations are dedicated to supporting education and research in primary sclerosing […]
The latest episode of the Global Kidney Care Podcast, a collaborative effort by the International Society of Nephrology (ISN), the International Society for Peritoneal Dialysis (ISPD), and Arbor Research Collaborative for Health, was released on June 3, 2024. This special episode focuses on Arbor Research’s Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS), a groundbreaking […]
Ann Arbor, MI — The American Heart Association has released a new scientific statement titled “Implementation of Obesity Science Into Clinical Practice: A Scientific Statement From the American Heart Association,” in its flagship scientific journal Circulation. This statement underscores the pressing need to bridge the gap between obesity research and real-world application in clinical settings. […]
Arbor Research Collaborative for Health (Arbor Research), a leading provider of innovative solutions in healthcare research, is pleased to announce its participation in the upcoming World Congress of Nephrology (WCN) 2024, scheduled to take place from April 13th to 16th, 2024. The WCN 2024 conference, organized by the International Society of Nephrology (ISN), is a […]